Lookup for "220 4.2.1"
Temporary Error - This status code indicates a transient issue and may resolve itself.
Basic Status Code Details (220)
Enhanced Status Code Details (4.2.1)
Mailbox disabled, not accepting messages
The mailbox exists, but is not accepting messages. This may be a permanent error if the mailbox will never be re-enabled or a transient error if the mailbox is only temporarily disabled.