Lookup for "221 4.4.3"
Temporary Error - This status code indicates a transient issue and may resolve itself.
Basic Status Code Details (221)
Enhanced Status Code Details (4.4.3)
Directory server failure
The network system was unable to forward the message, because a directory server was unavailable. This is useful only as a persistent transient error. The inability to connect to an Internet DNS server is one example of the directory server failure error.