Lookup for "421 5.6.3"
Permanent Error - This status code indicates a permanent issue and is unlikely to resolve itself. You should contact the Email Service Provider.
Basic Status Code Details (421)
Enhanced Status Code Details (5.6.3)
Conversion required but not supported
The message content must be converted in order to be forwarded but such conversion is not possible or is not practical by a host in the forwarding path. This condition may result when an ESMTP gateway supports 8bit transport but is not able to downgrade the message to 7 bit as required for the next hop.