Lookup for "450 2.2.1"
This status code indicates a successful delivery or other operation. Any details are simply notes.
Basic Status Code Details (450)
Requested mail action not taken: mailbox unavailable [E.g., mailbox busy]
Enhanced Status Code Details (2.2.1)
Mailbox disabled, not accepting messages
The mailbox exists, but is not accepting messages. This may be a permanent error if the mailbox will never be re-enabled or a transient error if the mailbox is only temporarily disabled.