Lookup for "450 4.1.6"
Temporary Error - This status code indicates a transient issue and may resolve itself.
Basic Status Code Details (450)
Requested mail action not taken: mailbox unavailable [E.g., mailbox busy]
Enhanced Status Code Details (4.1.6)
Destination mailbox has moved, No forwarding address
The mailbox address provided was at one time valid, but mail is no longer being accepted for that address. This code is only useful for permanent failures.