Lookup for "450 5.4.1"
Permanent Error - This status code indicates a permanent issue and is unlikely to resolve itself. You should contact the Email Service Provider.
Basic Status Code Details (450)
Requested mail action not taken: mailbox unavailable [E.g., mailbox busy]
Enhanced Status Code Details (5.4.1)
No answer from host
The outbound connection attempt was not answered, because either the remote system was busy, or was unable to take a call. This is useful only as a persistent transient error.