Lookup for "450 5.5.1"
Permanent Error - This status code indicates a permanent issue and is unlikely to resolve itself. You should contact the Email Service Provider.
Basic Status Code Details (450)
Requested mail action not taken: mailbox unavailable [E.g., mailbox busy]
Enhanced Status Code Details (5.5.1)
Invalid command
A mail transaction protocol command was issued which was either out of sequence or unsupported. This is useful only as a permanent error.