Lookup for "450 5.7.1"
Permanent Error - This status code indicates a permanent issue and is unlikely to resolve itself. You should contact the Email Service Provider.
Basic Status Code Details (450)
Requested mail action not taken: mailbox unavailable [E.g., mailbox busy]
Enhanced Status Code Details (5.7.1)
Delivery not authorized, message refused
The sender is not authorized to send to the destination. This can be the result of per-host or per-recipient filtering. This memo does not discuss the merits of any such filtering, but provides a mechanism to report such. This is useful only as a permanent error.