Lookup for "450 5.7.4"
Permanent Error - This status code indicates a permanent issue and is unlikely to resolve itself. You should contact the Email Service Provider.
Basic Status Code Details (450)
Requested mail action not taken: mailbox unavailable [E.g., mailbox busy]
Enhanced Status Code Details (5.7.4)
Security features not supported
A message contained security features such as secure authentication that could not be supported on the delivery protocol. This is useful only as a permanent error.