Lookup for "451 2.2.1"
This status code indicates a successful delivery or other operation. Any details are simply notes.
Basic Status Code Details (451)
Requested action aborted: local error in processing
Enhanced Status Code Details (2.2.1)
Mailbox disabled, not accepting messages
The mailbox exists, but is not accepting messages. This may be a permanent error if the mailbox will never be re-enabled or a transient error if the mailbox is only temporarily disabled.