Lookup for "452 5.4.6"
Permanent Error - This status code indicates a permanent issue and is unlikely to resolve itself. You should contact the Email Service Provider.
Basic Status Code Details (452)
Requested action not taken: insufficient system storage
Enhanced Status Code Details (5.4.6)
Routing loop detected
A routing loop caused the message to be forwarded too many times, either because of incorrect routing tables or a user-forwarding loop. This is useful only as a persistent transient error.