Lookup for "500 5.3.3"
Permanent Error - This status code indicates a permanent issue and is unlikely to resolve itself. You should contact the Email Service Provider.
Basic Status Code Details (500)
Syntax error, command unrecognized [This may include errors such as command line too long]
Enhanced Status Code Details (5.3.3)
System not capable of selected features
Selected features specified for the message are not supported by the destination system. This can occur in gateways when features from one domain cannot be mapped onto the supported feature in another.