Lookup for "500 5.4.6"
Permanent Error - This status code indicates a permanent issue and is unlikely to resolve itself. You should contact the Email Service Provider.
Basic Status Code Details (500)
Syntax error, command unrecognized [This may include errors such as command line too long]
Enhanced Status Code Details (5.4.6)
Routing loop detected
A routing loop caused the message to be forwarded too many times, either because of incorrect routing tables or a user-forwarding loop. This is useful only as a persistent transient error.