Lookup for "500 5.5.3"
Permanent Error - This status code indicates a permanent issue and is unlikely to resolve itself. You should contact the Email Service Provider.
Basic Status Code Details (500)
Syntax error, command unrecognized [This may include errors such as command line too long]
Enhanced Status Code Details (5.5.3)
Too many recipients
More recipients were specified for the message than could have been delivered by the protocol. This error should normally result in the segmentation of the message into two, the remainder of the recipients to be delivered on a subsequent delivery attempt. It is included in this list in the event that such segmentation is not possible.