Lookup for "501 5.4.2"
Permanent Error - This status code indicates a permanent issue and is unlikely to resolve itself. You should contact the Email Service Provider.
Basic Status Code Details (501)
Syntax error in parameters or arguments
Enhanced Status Code Details (5.4.2)
Bad connection
The outbound connection was established, but was unable to complete the message transaction, either because of time-out, or inadequate connection quality. This is useful only as a persistent transient error.